Histamine Intolerance: A common cause of chronic complaints
Krista Moyer ND

Dermatology can be annoyingly difficult to navigate, since each condition can have so many different presentations. My goal in this article is to introduce you to the possibility that histamine intolerance may be the root cause of many cases of atopic dermatitis.

Histamine is a well-known cause of seasonal allergies and pruritic rashes; however, there is a whole other world of bodily functions that can be caused by histamine dysregulation (Table 1).

Histamine is a neurotransmitter that is a part of the immune system, and is released by mast cells. There are 2 main enzymes that break down histamine. The enzyme in the central nervous system is histamine N-methyltransferase (HMT), and the enzyme within the digestive system is diamine oxidase (DAO). This article will focus on dysfunction of the DAO enzyme. Read More